After major trauma.

N Engl J Med 1996, 335:701-707. Ginzburg E, Cohn

After major trauma. N Engl J Med 1996, 335:701-707. Ginzburg E, Cohn SM, Lopez J, Jackowski J, Brown M, Hameed SM: Randomized clinical trial of intermittent pneumatic compression and low molecular weight heparin in trauma. Br J Surg 2003, 90:1338-1344. The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Cook D, Meade M, Guyatt G, Walter S, Heels-Ansdell D, Warkentin TE, Zytaruk N, Crowther M, 3-(Octyloxy)azetidine Geerts W, Cooper DJ, Vallance S, Qushmaq I,524.525.526.527.528.529.530.531. 532.533.534.Rocha M, Berwanger O, Vlahakis NE: Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med 2011, 364:1305-1314. 3,3-Dimethyl-7-nitro-2,3-dihydrobenzo[b][1,4]oxazepin-4(5h)-one Lubenow N, Hinz P, Thomaschewski S, Lietz T, Vogler M, Ladwig A, Junger M, Nauck M, Schellong S, Wander K, Engel G, Ekkernkamp A, Greinacher A: The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia. Blood 2010, 115:1797-1803. Ho KM, Chavan S, Pilcher D: Omission of early thromboprophylaxis and mortality in critically ill patients: a multicenter registry study. Chest 2011, 140:1436-1446. Jacobsen AF, Skjeldestad FE, Sandset PM: Ante- and postnatal risk factors of venous thrombosis: a hospital-based case-control study. J Thromb Haemost 2008, 6:905-912. Barleben A, Jafari F, Rose J Jr, Dolich M, Malinoski D, Lekawa M, Hoyt D, Cinat M: Implementation of a cost-saving algorithm for pelvic radiographs in blunt trauma patients. J Trauma 2011, 71:582-584. Magnotti LJ, Schroeppel TJ, Fabian TC, Clement LP, Swanson JM, Fischer PE, Bee TK, Maish GO III, Minard G, Zarzaur BL, Croce MA: Reduction in inadequate empiric antibiotic therapy for ventilator-associated pneumonia: impact of a unit-specific treatment pathway. Am Surg 2008, 74:516-522, discussion 522-523. Rice TW, Morris S, Tortella BJ, Wheeler AP, Christensen MC: Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients. Crit Care Med 2012, 40:778-786. Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat AH, Dellinger EP, Herbosa T, Joseph S, Kibatala PL, Lapitan MC, Merry AF, Moorthy K, Reznick RK, Taylor B, Gawande AA, Safe Surgery Saves Lives Study Group: A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med 2009, 360:491-499. Davidson GH, Hamlat CA, Rivara FP, Koepsell TD, Jurkovich GJ, Arbabi S: Long-term survival of adult trauma patients. JAMA 2011, 305:1001-1007. Moore L, Turgeon AF, Emond M, Le Sage N, Lavoie A: Definition of mortality for trauma center performance evaluation: a comparative study. Crit Care Med 2011, 39:2246-2252. Kalhan R, Mikkelsen M, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/18218841 Dedhiya P, Christie J, Gaughan C, Lanken PN, Finkel B, Gallop R, Fuchs BD: Underuse of lung protective ventilation: 2-dioxaborolan-2-yl)benzoate N-Benzyl-5-chloro-3-isopropylpyrazolo[1 analysis of potential factors to explain physician behavior. Crit Care Med 2006, 34:300-306. Brunkhorst FM, Engel C, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/22993420 Ragaller M, Welte T, Rossaint R, Gerlach H, Mayer K, John S, Stuber F, Weiler N, Oppert M, Moerer O, Bogatsch H, Reinhart K, Loeffler M, Hartog C, German Sepsis Competence Network (SepNet): Practice and perception nationwide survey of therapy habits in sepsis. Crit Care Med 2008, 36:2719-2725.doi:10.1186/cc12685 Cite this article as: Spahn et al.: Management of bleeding and coagulopathy following major trauma: an updated European guideline. Critical Care 2013 17:R76.Submit your next manuscript to BioMed Central and take full a.